SYNTHESIS AND BIOLOGICAL ACTIVITY STUDY OF NEW SCHIFF AND MANNICH BASE LIGANDS DERIVED FROM ISATIN AND 3- AMINO-1,2,4 -TRIAZOLE AND THEIR METAL COMPLEXES

Author (s) : R.Kavitha, R.Senbahavalli, G.Sivasakthi, M.Manju

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Abstract :
Two new Mannich and Schiff base ligands namely: (1-(3`-amino-methyl-1`(H)-1`,2`,4`-triazole)-3-(1`(H)-1`,2`,4`- triazole-3`-yl) iminoisatin (LI) and 1-morpholinomethyl-3-(1`(H)-1`,2`,4`-triazolyl)iminoisatin (LII) were prepared from condensationreaction of the new Schiff base 3-(1`(H)-1`,2`,4`-triazole-3`-yl)iminoisatin (SBH) (0.01 mol) with formaldehyde and 3-amino-1,2,4-triazole (3-At) or with formaldehyde and morpholine (0.01 mole each) respectively. Structures were characterized by 1H NMR, CHN analyses, mass spectra and IR spectra. Metal complexes were synthesized by heating each ligand (0.02 mol) with metal salts (0.01 mol) in ethanol or ethanol: acetone mixture respectively. The formula of metal complexes were suggested depending on CHN and thermal analyses, metal and chloride contents, IR and UV-visible spectra, magnetic moments (μeff) and conductivity measurements. All complexes were of octahedral geometry except palladium (II) complexes which were square planar. The two ligands and some selected metal complexes showed various antibacterial and cytotoxic effects.

Keywords : Mannich Schiff base, isatin, 3-amino-1,2,4,-triazole.

Conference Date : 13/11/2020

Pages : 126

Paper ID : 20126